What is PERTZYE® (pancrelipase)?
PERTZYE can help you digest food
PERTZYE is a prescription medicine used to treat people with exocrine pancreatic insufficiency (EPI) due to cystic fibrosis (CF). It’s for people who can’t digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis. PERTZYE helps simulate normal pancreatic digestive function, so you can provide adequate nutrition for your body.
PERTZYE contains pancreatic enzymes buffered with bicarbonate
Each delayed-release capsule of PERTZYE contains coated beads, called microspheres. These microspheres of varying sizes, protect and carry 3 types of pancreatic enzymes (amylase, protease, and lipase) normally made by a healthy pancreas and bicarbonate to your duodenum (first part of the small intestine).
What role does bicarbonate play in your digestion?
Once in the duodenum, the microspheres dissolve and release the pancreatic enzymes and bicarbonate buffer to mix with food as it passes out of the stomach. Bicarbonate is released alongside the enzymes, which may help to increase the pH of the area around the enzymes. This may be important because the food mixture coming from the stomach has a low (acidic) pH, and pancreatic enzymes can be destroyed by a low pH.
*The PERTZYE formulation also contains other inactive ingredients.See how PERTZYE works inside your digestive system
Pancreatic enzymes are affected by pH
People with EPI due to CF have a more acidic small intestine than healthy people.
Important Safety Information
PERTZYE® (pancrelipase) may increase the risk of having a rare bowel disorder called fibrosing colonopathy, especially if taken at a high dose in children with cystic fibrosis who are less than 12 years of age. This condition is serious and may require surgery. The risk of having fibrosing colonopathy may be reduced by following the dosing instructions that your doctor gives you. Call your doctor right away if you have any unusual or severe stomach area (abdominal) pain, bloating, trouble passing stools (constipation), nausea, vomiting, or diarrhea.
Take PERTZYE capsules exactly as your doctor tells you. You should not switch PERTZYE with any other pancreatic enzyme product without first talking with your doctor. Don’t take more capsules in a day than the number your doctor tells you to take (total daily dose). Always take PERTZYE with a meal or snack and plenty of fluid. If you eat a lot of meals or snacks in a day, be careful not to go over your total daily enzyme dose. PERTZYE capsules should be swallowed whole. Do not crush or chew the PERTZYE capsules or their contents, and do not hold the capsule or capsule contents in your mouth. Read the Medication Guide for instructions on how to take PERTZYE if you have trouble swallowing capsules.
The most common side effects of PERTZYE include diarrhea, upset stomach (indigestion), and cough. Other potential serious side effects are irritation of the inside of your mouth; increase in blood uric acid levels, which may cause worsening of swollen, painful joints (gout); and allergic reactions, including trouble swallowing or breathing, skin rash, itching, or swelling of your face, eyes, lips, tongue, or throat. Call your doctor right away if you have any of these symptoms.
Tell your doctor about all of your medical conditions, including if you are allergic to pork (pig) products, have a history of blockage of your intestines, or scarring or thickening of your bowel wall (fibrosing colonopathy), have gout, kidney disease, or high blood uric acid (hyperuricemia), have trouble swallowing capsules, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Tell your doctor about all the medicines you take.
PERTZYE and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.
Uses for PERTZYE Delayed-Release Capsules
PERTZYE is a prescription medicine used to treat people who can’t digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis or other conditions.
PERTZYE capsules contain a mixture of digestive enzymes, including lipases, proteases, and amylases, from pig pancreas. PERTZYE is safe and effective in children and adults when taken as prescribed by your doctor.
Click here to read the Full Prescribing Information and Medication Guide before you start taking PERTZYE. You should also read the insert that comes with each prescription refill because there may be new information.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
References available upon request.