What is PERTZYE® (pancrelipase)?

PERTZYE can help you digest food

3 types of pancreatic enzymes: Lipase, amylase, protease + bicarbonate buffer = the PERTZYE microsphere

If you have been prescribed PERTZYE, your doctor has decided that it may be the right pancreatic enzyme product to help you digest food so you can provide adequate nutrition for your body.

For people with exocrine pancreatic insufficiency (EPI) due to cystic fibrosis, PERTZYE helps simulate normal pancreatic digestive function.

What role does bicarbonate play in your digestion?

Each delayed-release capsule of PERTZYE contains coated beads called microspheres. These microspheres (in varying sizes) protect and carry pancreatic enzymes (lipase, amylase, protease) and bicarbonate to the duodenum.

Once there, the coating dissolves and the microspheres release the pancreatic enzymes and bicarbonate to mix with food as it passes out of the stomach.

The bicarbonate may help increase the pH of the area around the enzymes to enable them to work better to digest food.

This may be important because the food mixture coming from the stomach has a low (acidic) pH, and pancreatic enzymes can be destroyed by a low pH.

See how PERTZYE works in the digestive system >


pH: What does it mean?

The pH of a substance is the measure that lets you know if it is acidic, neutral, or basic

pH scale

Proven effective in clinical trials

In a study of children and adults with EPI due to cystic fibrosis, PERTZYE:

  • Increased the amount of fat and protein absorbed
  • Helped reduce the number of bowel movements and the amount of stool produced

The average PERTZYE dose taken during the study was in the middle of the dosing range recommended by Cystic Fibrosis Foundation Consensus Conferences, the leading authority on the treatment of EPI in cystic fibrosis.

PERTZYE may increase your chance of having a rare bowel disorder called fibrosing colonopathy. This condition is serious and may require surgery. The risk of having this condition may be reduced by following the dosing instructions that your doctor gave you.