Support During COVID-19

COVID-19 frequently asked questions

Chiesi is fully committed to supporting patients with cystic fibrosis during these difficult times. As always, Chiesi CareDirect® is available to give eligible patients access to prescription savings and financial assistance.

Should I stop or skip taking my medicine?+

I’ve lost insurance coverage due to job loss. How can Chiesi CareDirect help?+

I still have insurance issued through my employer or pay for private insurance. Are there still opportunities for me to be saving money on my treatment?+

I have Medicare and am interested in finding more financial support. What resources are available?+

Should I be concerned about the production and supply of PERTZYE?+

*Restrictions apply. Limit one card per person per month. Patients receiving Medicare, Medicaid, or that are participating in any other state or federally subsidized pharmacy benefit program are not eligible for certain components of this program. Please see full Terms and Conditions.

Patients receive $75 per month with every PERTZYE refill (annual savings: $900). Patients receiving Medicare, Medicaid, or that are participating in any other state or federally subsidized pharmacy benefit program are not eligible for certain components of this program. Please see full Terms and Conditions.

Find out what resources are available for you.

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Contact a Chiesi CareDirect Specialist toll-free at 1-888-865-1222 from 9:00 am to 8:00 pm ET, Monday through Friday.

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You can also email

Important Safety Information

PERTZYE® (pancrelipase) may increase the risk of having a rare bowel disorder called fibrosing colonopathy, especially if taken at a high dose in children with cystic fibrosis who are less than 12 years of age. This condition is serious and may require surgery. The risk of having fibrosing colonopathy may be reduced by following the dosing instructions that your doctor gives you. Call your doctor right away if you have any unusual or severe stomach area (abdominal) pain, bloating, trouble passing stools (constipation), nausea, vomiting, or diarrhea.

Take PERTZYE capsules exactly as your doctor tells you. You should not switch PERTZYE with any other pancreatic enzyme product without first talking with your doctor. Don’t take more capsules in a day than the number your doctor tells you to take (total daily dose). Always take PERTZYE with a meal or snack and plenty of fluid. If you eat a lot of meals or snacks in a day, be careful not to go over your total daily enzyme dose. PERTZYE capsules should be swallowed whole. Do not crush or chew the PERTZYE capsules or their contents, and do not hold the capsule or capsule contents in your mouth. Read the Medication Guide for instructions on how to take PERTZYE if you have trouble swallowing capsules.

The most common side effects of PERTZYE include diarrhea, upset stomach (indigestion), and cough. Other potential serious side effects are irritation of the inside of your mouth; increase in blood uric acid levels, which may cause worsening of swollen, painful joints (gout); and allergic reactions, including trouble swallowing or breathing, skin rash, itching, or swelling of your face, eyes, lips, tongue, or throat. Call your doctor right away if you have any of these symptoms.

Tell your doctor about all of your medical conditions, including if you are allergic to pork (pig) products, have a history of blockage of your intestines, or scarring or thickening of your bowel wall (fibrosing colonopathy), have gout, kidney disease, or high blood uric acid (hyperuricemia), have trouble swallowing capsules, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Tell your doctor about all the medicines you take.

PERTZYE and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

Uses for PERTZYE Delayed-Release Capsules

PERTZYE is a prescription medicine used to treat people who can’t digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis or other conditions.

PERTZYE capsules contain a mixture of digestive enzymes, including lipases, proteases, and amylases, from pig pancreas. PERTZYE is safe and effective in children and adults when taken as prescribed by your doctor.

Click here to read the Full Prescribing Information and Medication Guide before you start taking PERTZYE. You should also read the insert that comes with each prescription refill because there may be new information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Terms and Conditions

PERTZYE $0 Copay Assistance Program: Available to patients with commercial insurance. Patients pay $0 out-of-pocket costs toward their PERTZYE prescription up to a monthly maximum of $1440. To obtain this benefit, patients must be enrolled in Chiesi CareDirect and utilize one of the network specialty pharmacies. Upon enrollment, the offer is valid for 12 months of copay assistance. Patients with primary enrollment in government-funded plans are not eligible for copay assistance.

PERTZYE $20 Copay Card Program: By signing up for the PERTZYE Co-Pay Card Program, Patient acknowledges that they agree to comply with all the Terms & Conditions listed below. Keep this savings coupon with you for future refills. Please call 1-855-883-1461 if you encounter any issues.

Patient Terms of Use: Please present this coupon and your PERTZYE prescription to your Pharmacist. Patient is responsible for the first $20 of their co-pay and for any co-pay amount or out-of-pocket expense above their actual maximum savings benefit up to $500. Offer good for 12 refills, limit one card per Patient. Other restrictions may apply. Patient is responsible for applicable taxes, if any.

Non-transferable, cannot be combined with any other offer. Void where prohibited by law, taxed, or restricted. Patients, pharmacists, and prescribers cannot seek reimbursement from health insurance or any third party for any part of the benefit received by the patient through this offer. Chiesi reserves the right to rescind, revoke, or amend this offer, eligibility, and terms of use at any time without notice.

ELIGIBILITY: Patients are eligible for this offer if: their private insurance co-pay is more than $20; or, they are a cash-paying Patient. Patients who are enrolled in a state or federally funded prescription insurance program are not eligible for this offer. This includes patients enrolled in Medicare Part D, Medicaid, Medigap, Veterans Affairs (VA), Department of Defense (DOD) programs, or TriCare, patients who are Medicare eligible and enrolled in an employer-sponsored group waiver health plan or government-subsidized prescription drug benefit program for retirees, and Puerto Rico Government Health Insurance Plan. Patients who move from a commercial plan to a government plan will lose eligibility. Must be 18 or older to receive assistance for themselves or a minor. Patients receiving 100% reimbursement from their insurance are not eligible. This offer is not insurance and is restricted to residents of the United States and Puerto Rico. Only good at participating pharmacies. Distribution or use of the Co-Pay Card does not obligate use or continuing use of any specific product or provider.

PHARMACY: Restat has been authorized to reimburse you per your contracted rate plus the benefit paid with this coupon. This claim may be submitted electronically through Restat using the processing numbers on the front of this card or by mail. Submit all claims in NCPDP Standard D.0. Secondary processing should follow NCPDP standards for Co-Pay Only billing (other coverage code 3, 4, or 8); or by using Coordination of Benefits processing. Mail claims should go to Restat, 11900 W Lake Park Drive, Milwaukee, WI 53224 along with the copy of the pharmacy prescription receipt (cash register receipts are not accepted), and the return address. Retain a copy of this coupon and file with the prescription for auditing purposes. Call the Restat Help Desk at 1-866-450-3277 for processing questions.

360° Debit Card: is available to patients with commercial insurance. Patients must call 1-888-865-1222 to sign up for the 360° Debit Card. For every qualifying monthly prescription of PERTZYE that is filled, the patient can receive $75 to apply toward goods and services including nutritional foods, food services, food preparation tools, vitamins, supplements, probiotics, fitness monitoring devices, pedometers, gym memberships, and expenses related to treatment visits. This offer covers up to $225 for each 3-month supply of PERTZYE. Patients receiving Medicare, Medicaid, or that are participating in any other state or federally subsidized pharmacy benefit program are not eligible for the 360° Debit Card offer. Chiesi reserves the right to rescind, revoke, or amend this offer without notice at any time. This offer is good only in the U.S. The card and offer expire on 12/31/19. Patients participating in the PERTZYE Patient Assistance Program are not eligible.

PAP Eligibility Requirements:

  • Legal US resident
  • Income level within specified guidelines
  • Uninsured or underinsured:
    • Commercially insured patients w/o prescription coverage are eligible
    • Commercially insured patients with no plan coverage for product are eligible
    • Commercially insured patients appealing plan determination are eligible (during the appeal process)
  • Patients with a government-funded plan are not eligible for PAP (Medicare Part D, Medicaid, etc.)
  • Commercially insured patients with high out-of-pocket costs are not considered eligible. Product is considered covered

References available upon request.