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    Important Safety Information

    Fibrosing colonopathy is associated with high-dose use of pancreatic enzyme replacement. Exercise caution when doses of PERTZYE exceed 2,500 lipase units/kg body weight per meal (or greater than 10,000 lipase units/kg body weight per day).

    To avoid irritation of oral mucosa, do not chew PERTZYE or retain in the mouth.

    Hyperuricemia may develop. Consider monitoring uric acid levels in patients with hyperuricemia, gout, or renal impairment.

    There is theoretical risk of viral transmission with all pancreatic enzyme products including PERTZYE.

    Exercise caution when administering pancrelipase to a patient with a known allergy to proteins of porcine origin.

    Most common adverse reactions (≥10%) are: diarrhea, dyspepsia, and cough.


    PERTZYE® (pancrelipase) is indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis or other conditions.

    Please click here for Full Prescribing Information and Medication Guide.