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For the treatment of exocrine pancreatic
insufficiency (EPI) due to cystic fibrosis (CF)
PERTZYE® (pancrelipase) microspheres are
uniquely formulated to simulate normal
pancreatic digestive function1-4

PERTZYE microspheres contain 3 types of pancreatic enzymes: lipase, amylase, and protease.3

These enzymes are buffered with bicarbonate, which may help to optimize the microenvironment pH.2

3 microspheres
  • BICARBONATE BUFFER
    may help optimize enzyme activity5,6
  • ENTERIC-COATED MICROSPHERES
    to bypass gastric acid3
  • VARYING SIZES
    to extend the window of enzyme release7,8

PERTZYE does not require concomitant use of acid-suppressing drugs.3

“The Cystic Fibrosis Foundation Consensus Conferences state that poor dissolution of the enteric coating and release of the enzymes all at once are factors contributing to a poor response to therapy.” 1

How does PERTZYE work within the digestive system? Review mechanism of action for PERTZYE.

How does PERTZYE work
within the digestive system?

Review mechanism of action for PERTZYE >

PERTZYE achieved significant improvements vs placebo3,9

Increased

FAT

ABSORPTION

Increased

PROTEIN

ABSORPTION

Decreased

STOOL

WEIGHT AND FREQUENCY

Most common adverse reactions ( 10%) are: diarrhea, dyspepsia, and cough.