For patients with exocrine pancreatic insufficiency due to cystic fibrosis or other conditions

Fuels you forward

PERTZYE® (pancrelipase) is formulated to contain pancreatic enzymes buffered with bicarbonate for nutrient absorption that gives you the opportunity to thrive

What is PERTZYE?

PERTZYE is used to treat people who can’t digest food normally because their pancreas does not make enough enzymes. PERTZYE microspheres (in varying sizes) protect and carry pancreatic enzymes (lipase, amylase, protease) and bicarbonate to the duodenum to help you better digest food.

The PERTZYE formulation also contains other inactive ingredients.

Each delayed-release capsule of PERTZYE (pancrelipase) is made of pancreatic enzymes with a bicarbonate buffer.
A PERTZYE (pancrelipase) patient (young girl) is at the beach with her boogie board

PERTZYE offers multiple dosing and delivery options that may fit your needs

As you grow, your dose of PERTZYE may change due to your age, diet, and weight. With our flexible dosing and delivery options, you can work with your doctor to create an individualized treatment plan that may work for you.

Eligible patients can save every month on their prescription of PERTZYE (pancrelipase)

A savings and support program designed to help you

Join our free support program that offers eligible patients $0 copay, $75 debit card, one-on-one support, and free supplies of PERTZYE‡ §

Chiesi is dedicated to the cystic fibrosis community

Learn more about another CF product>

*Restrictions apply. Limit one card per person per month. Patients receive $75 per month with every PERTZYE refill (annual savings: $900). Patients receiving Medicare, Medicaid, or that are participating in any other state or federally subsidized pharmacy benefit program are not eligible for certain components of this program. Please see full Terms and Conditions.
‡Restrictions apply. Limit one card per person per month. Patients receiving Medicare, Medicaid, or that are participating in any other state or federally subsidized pharmacy benefit program are not eligible for certain components of this program. Please see full Terms and Conditions.
§Free supply of PERTZYE is provided by Digestive Care, Inc. PERTZYE is shipped directly to patients and may also be available at doctor’s office.

Important Safety Information

PERTZYE® (pancrelipase) may increase the risk of having a rare bowel disorder called fibrosing colonopathy, especially if taken at a high dose in children with cystic fibrosis who are less than 12 years of age. This condition is serious and may require surgery. The risk of having fibrosing colonopathy may be reduced by following the dosing instructions that your doctor gives you. Call your doctor right away if you have any unusual or severe stomach area (abdominal) pain, bloating, trouble passing stools (constipation), nausea, vomiting, or diarrhea.

Take PERTZYE capsules exactly as your doctor tells you. You should not switch PERTZYE with any other pancreatic enzyme product without first talking with your doctor. Don’t take more capsules in a day than the number your doctor tells you to take (total daily dose). Always take PERTZYE with a meal or snack and plenty of fluid. If you eat a lot of meals or snacks in a day, be careful not to go over your total daily enzyme dose. PERTZYE capsules should be swallowed whole. Do not crush or chew the PERTZYE capsules or their contents, and do not hold the capsule or capsule contents in your mouth. Read the Medication Guide for instructions on how to take PERTZYE if you have trouble swallowing capsules.

The most common side effects of PERTZYE include diarrhea, upset stomach (indigestion), and cough. Other potential serious side effects are irritation of the inside of your mouth; increase in blood uric acid levels, which may cause worsening of swollen, painful joints (gout); and allergic reactions, including trouble swallowing or breathing, skin rash, itching, or swelling of your face, eyes, lips, tongue, or throat. Call your doctor right away if you have any of these symptoms.

Tell your doctor about all of your medical conditions, including if you are allergic to pork (pig) products, have a history of blockage of your intestines, or scarring or thickening of your bowel wall (fibrosing colonopathy), have gout, kidney disease, or high blood uric acid (hyperuricemia), have trouble swallowing capsules, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Tell your doctor about all the medicines you take.

PERTZYE and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

Uses for PERTZYE Delayed-Release Capsules

PERTZYE is a prescription medicine used to treat people who can’t digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis or other conditions.

PERTZYE capsules contain a mixture of digestive enzymes, including lipases, proteases, and amylases, from pig pancreas. PERTZYE is safe and effective in children and adults when taken as prescribed by your doctor.

Click here to read the Full Prescribing Information and Medication Guide before you start taking PERTZYE. You should also read the insert that comes with each prescription refill because there may be new information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

References available upon request.